Modulatory effect of quercetin on azathioprine induced membrane changes in the mouse spleen
Chitra, S.; Devipriya, S.; Shyamala Devi, C.S.
Indian Journal of Experimental Biology 39(2): 132-136
2001
ISSN/ISBN: 0019-5189 PMID: 11480208 Document Number: 536038
Modulatory effect of quercetin on azathioprine induced toxic changes was studied in spleen of experimental animals. Azathioprine treatment caused an increase in serum albumin/globin ratio and a decrease in total protein in spleen tissue. An increase in a membrane bound ATPases was also noted. Supplementation of quercetin with azathioprine increased the protein content and lowered the activities of membrane ATPase in spleen. There was a decrease in serum albumin globulin ratio. It was concluded that quercetin modulated the protein and membrane bound ATPase activities and protected the spleen from azathioprine induced membrane damage.