Protective mechanism of tianmacuzhi granules in brain
Cao, C.Y.; Du, G.Y.; Zuo, P.P.; Liu, X.F.; Wang, W.T.; Zhao, Y.; Wang, X.R.; Cui, H.F.
Zhongguo Zhong Yao Za Zhi 26(4): 269-272
2001
ISSN/ISBN: 1001-5302 PMID: 12525053 Document Number: 535503
To provide pharmacological evidence for the protective effects of Tianmacuzhi Granules (TMC) in mouse brain in a ischemia--reperfusion model. Receptor binding test of NMDA receptor and M receptor in brain, GPx activity determination in brain and liver effected by different dose of TMC were performed. TMC could reduce the NMDA receptor activity, increase the M receptor activity and GPx activity of cerebral cortex and hippocampus tissues significantly. TMC might antagonize ischemia-reperfusion injury of brain by reducing the glutamate neurotoxicity and increasing the function of cholinergic nerve and effects of anti-peroxidization in brain.