Gastrointestinal metabolism of gallium and indium: effect of iron deficiency
Valberg, L.S.; Flanagan, P.R.; Haist, J.; Frei, J.V.; Chamberlain, M.J.
Clinical and Investigative Medicine. Medecine Clinique et Experimentale 4(2): 103-108
1981
ISSN/ISBN: 0147-958X PMID: 7285398 Document Number: 5351
Mice given an intragastric dose of 100 nmol of gallium or indium chloride labelled with 67Ga or 114mIn absorbed less than 0.5% of each. Duodenal perfusions in mice fed a purified iron-supplemented diet showed that 59Fe, 67Ga and 114mIn were taken up by the intestinal mucosa but only iron was absorbed. Dietary iron deficiency enhanced both the duodenal uptake of iron and its absorption, but it had no significant effect on the uptake and absorption of gallium and indium. In the perfused duodenal loops gallium caused mitochondrial degeneration and swelling, whereas indium produced degeneration of microvilli and fatty degeneration of epithelial cells. After intramuscular injections of gallium and indium, 45 and 21% of the doses, respectively, were excreted within 24 h, and after only 4 h significant amounts of both metals were present in the wall of the gastrointestinal tract and in luminal washings; the highest concentrations were found in the wall of the middle and distal small intestine. These results indicate that gallium and indium are poorly absorbed from the gastrointestinal tract, that iron deficiency does not enhance the uptake or transfer of either metal and that the intestinal tract serves as a route for the excretion of parenterally administered gallium and indium.
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