Top Abstract Purchase Related
Home
>
Node
>
Subnode

Mechanisms of mice resistance to influenza virus A/AICHI/2/68 after preventive injection with polyprenols

Shishkina, L.N.; Safatov, A.S.; Sergeev, A.N.; P'iankov, O.V.; Poryvaev, V.D.; Bulychev, L.E.; Petrishchenko, V.A.; P'iankova, O.G.; Zhukov, V.A.; Ryzhikov, A.B.; Boldyrev, A.N.; Buriak, G.A.; Raldugin, V.A.; Kukina, T.P.

Voprosy Virusologii 46(3): 34-38

2001

ISSN/ISBN: 0507-4088
PMID: 11450142
Document Number: 533842
Preventive effect in influenza can be attained by intramuscular injections of fir (Abies) polyprenols. One of 5 tested polyprenol preparations (No. 1), injected 2 days before aerogenic infection with influenza virus, reliably protected mice from disease. Mice pretreated with polyprenol preparations or Hanks' solution did not differ by accumulation of interferon in the lungs One day after aerogenic infection. Three days after injection of polyprenol preparation No. 1 the weights of the spleen and thymus significantly decreased. One day after injection cell count in the bronchoalveolar tract of mice was almost 2-fold higher than in the control at the expense of lymphocytes and macrophages. After 3 days the relative and absolute counts of macrophages decreased and those of lymphocytes decreased significantly. Three days after injection macrophages were 2-fold more active in absorption of zymosan granules. Preparation No. 1 affected the production of superoxide anion radicals, whose production by all macrophages in the bronchoalveolar tract of mice was significantly higher on day 1 postinjection than on day 3 and higher than on days 1 and 3 after injection of preparation No. 2.

Document emailed within 1 workday
Secure & encrypted payments

Shishkina, L.N.; Safatov, A.S.; Sergeev, A.N.; Zhukov, V.A.; Bulychev, L.E.; P'iankov, O.V.; Poryvaev, V.D.; P'iankova, O.G.; Buriak, G.A.; Goncharova, E.P. 2001: Mechanisms of action of aerosol preparations based on Abies siberica polyprenols in experimental influenza infection Voprosy Virusologii 46(6): 28-33
Shilov, A.A.; Sinitsyn, B.V. 1994: Changes in its hemagglutinin during the adaptation of the influenza virus to mice and their role in the acquisition of virulent properties and resistance to serum inhibitors Voprosy Virusologii 39(4): 153-157
Nau, J.-Y. 2006: Influenza virus of seasonal influenza , high increase of resistance to amantadine and rimantadine Revue Medicale Suisse 2(50): 308
Markushin, S.G.; Akopova, I.I.; Koptiaeva, I.B.; Tsfasman, T.M.; Gendon, I.Z. 2006: Molecular mechanisms of reversions to the ts+ -phenotype of cold-adapted influenza virus a strains--attenuation donors for live influenza reassortant vaccines Voprosy Virusologii 51(5): 17-22
Zarubaev, V.V.; Garshinina, A.V.; Kalinina, N.A.; Shtro, A.A.; Beliaevskaia, S.V.; Nebol'sin, V.E.; Kiselev, O.I. 2010: Protective activity of Ingavirin in experimental lethal influenza due to pandemic influenza virus a (H1N1)v in albino mice Antibiotiki i Khimioterapiia 55(5-6): 24-31
Radomińska-Pyrek, A.; Chojnacki, T.; Zulczyk, W. 1979: Acyl esters of polyprenols: specificity of microsomal transacylase for polyprenols of different chain length and saturation Acta Biochimica Polonica 26(1-2): 125-134
Courcambeck, J.ér.ôm.; Bouzidi, M.; Perbost, R.ég.; Jouirou, B.; Amrani, N.; Cacoub, P.; Pèpe, G.ér.; Sabatier, J.-M.; Halfon, P. 2006: Resistance of hepatitis C virus to NS3-4A protease inhibitors: mechanisms of drug resistance induced by R155Q, A156T, D168A and D168V mutations Antiviral Therapy 11(7): 847-855
Huang, L.; Zhou, J.-F.; Wei, H.; Shu, Y.-L. 2012: Neuraminidase inhibitors resistance in influenza viruses and the related mechanisms Bing du Xue Bao 28(5): 572-576
Semkow, R.; Zgorzelska, K.; Brydak, L. 1971: Studies on the adaptation of freshly isolated strains of influenza virus. II. Endogenous respiration of the organs in virus-infected mice Medycyna Doswiadczalna i Mikrobiologia 23(2): 141-146
Kantorovich-Prokudina, E.N.; Kaverin, N.V.; Semenova, N.P.; Miasnikova, I.A.; Berezina, O.N. 1978: Preventive effect of UV-inactivated defective interfering influenza virus in experimental infection Voprosy Virusologii 1978(6): 673-677
Sergeev, A.N.; Safatov, A.S.; P'iankov, O.V.; Bulychev, L.E.; Zhukov, V.A.; Alekseeva, A.G.; Petrishchenko, V.A.; Shishkina, L.N.; Poryvaev, V.D.; Glotov, A.G. 2001: Prophylactic efficacy of aerosol preparations based on Abies siberica polyprenols in experimental influenza infection Voprosy Virusologii 46(6): 24-28
Pei, J-hao.; Zhou, Z-guang.; Luo, J-hua.; Jiang, T-jian.; Li, X.; He, L. 2004: Preventive effects of pioglitazone on diabetes and relevant mechanisms, experimental study on non-obese diabetic mice Zhonghua Yi Xue Za Zhi 84(5): 411-415
Alexandrescu, M.; Handrache, L.; Moroşanu, V.; Vancea, G.; Ionescu, L.; Colev, A. 1974: Influenza viruses and lympho-macrophagic cells. I. in vitro interaction between influenza A2-59 virus (H2N2) and peritoneal macrophagic cells from normal or immunized mice and rats Revue Roumaine de Virologie 25(1): 3-14
Reinacher, M.; Bonin, J.; Narayan, O.; Scholtissek, C. 1983: Pathogenesis of neurovirulent influenza a virus infection in mice. Route of entry of virus into brain determines infection of different populations of cells Laboratory Investigation; a Journal of Technical Methods and Pathology 49(6): 686-692
Alexandrescu, M.; Handrache, L.; Moroşanu, V.; Colev, A.; Vancea, G.; Ionescu, L. 1974: Influenza viruses and lympho-macrophagic cells. Note II. In vitro interaction between macrophagic cells from normal mice and purified influenza virus A/Laşi/59 (H2N2) in the presence of soluble lymphocytic mediators (lymphokins) Revue Roumaine de Virologie 25(3): 197-205
Stoeva, E.; Tantcheva, L.; Mileva, M.; Savov, V.; Galabov, A.S.; Braykova, A. 2001: Preventive effect of vitamin E on the processes of free radical lipid peroxidation and monooxygenase enzyme activity in experimental influenza virus infection Advances in Experimental Medicine and Biology 500: 257-260
Prahoveanu, E.; Boeru, V.; Teodosiu, O.; Petrescu, A. 1979: Susceptibility of irradiated mice to inoculation with two influenza virus strains Virologie 30(1): 29-35
Byshovets, T.F.; Topchiĭ, G.L. 1976: Immunologic reactivity of mice infected antenatally with influenza virus Mikrobiolohichnyi Zhurnal 38(5): 613-615
Xu, H.; Qian, Y.; Xu, H.; Zhang, J.-h.; Zhu, R.-n.; Wang, F. 2006: Resistance to amantadine of epidemic strain of H3 subtype influenza virus: a primary study Zhonghua Yi Xue Za Zhi 86(14): 996-998
Jin, L.; Sui, W.Z. 1986: Influence of berbamine on the immune function in mice infected with the influenza virus Zhongguo Yao Li Xue Bao 7(5): 475-479