Prognostication of obstructive syndrome in patients with chronic bronchitis considering hereditary factors
Ivchik, T.V.; Kokosov, A.N.; Razorenov, G.I.; Razorenova, T.S.; Iakovleva, N.G.
Terapevticheskii Arkhiv 73(3): 33-37
2001
ISSN/ISBN: 0040-3660 PMID: 11417177 Document Number: 533477
To propose method of accurate prediction of chronic obstructive pulmonary disease (COPD) at early stages of development. 92 males with COPD and 55 males with chronic non-obstructive bronchitis aged 38 to 72 years were examined according to a technique which identifies hereditary predisposition to multifactor diseases and using an algorithm based on multivariate analysis. An original mathematical model is proposed which can quantitatively examine and range by influence the role of environmental and hereditary factors in development of COPD. Detection of hereditary predisposition to COPD may be one of the objective criteria to recommend giving up smoking and for occupational orientation.