Effect of antibacterial therapy on the epidemic threat of experimental pneumonic plague in monkeys
Romanov, V.E.; Vasil'ev, N.T.; Shabalin, B.A.; Mironin, A.V.
Antibiotiki i Khimioterapiia 46(4): 16-18
2001
ISSN/ISBN: 0235-2990 PMID: 11550501 Document Number: 533460
High therapeutic efficacy of aminoglycosides, quinolones, cephalosporins and rifampicins was demonstrated in experiments performed on monkeys, infected aerogenically by Yersinia pestis 1300. Antibacterials inhibited Y. pestis cells reproduction in the infected animals organisms evaluated by dynamics of bacterial cells isolated from the blood and fauces of the animals. It was shown that antibacterial therapy prevented infection transmission from the infected animals. The time of respiratory tract sanitation was in the range from 12 to 48 hours after the treatment and depended on drug efficacy.