The effect of the methods for producing an experimental Marburg virus infection on the characteristics of the course of the disease in green monkeys

Bazhutin, N.B.; Belanov, E.F.; Spiridonov, V.A.; Voĭtenko, A.V.; Krivenchuk, N.A.; Krotov, S.A.; Omel'chenko, N.I.; Tereshchenko, A.I.; Khomichev, V.V.; Bazhutin, N.B; Belanov, E.F; Spiridonov, V.A; Voitenko, A.V; Krivenchuk, N.A; Krotov, S.A; Omel&apo; chenko, N.I; Tereshchenko, A.I; Khomichev, V.V

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The effect of the methods for producing an experimental Marburg virus infection on the characteristics of the course of the disease in green monkeys

Bazhutin, N.B.; Belanov, E.F.; Spiridonov, V.A.; Voĭtenko, A.V.; Krivenchuk, N.A.; Krotov, S.A.; Omel'chenko, N.I.; Tereshchenko, A.I.; Khomichev, V.V.

Voprosy Virusologii 37(3): 153-156

1992

ISSN/ISBN: 0507-4088

PMID: 1441442

Document Number: 402213

A comparative study on the features of the pathogenesis of Marburg disease after parenteral and aerosol infection of green monkeys with a virus prepared from native culture suspension and that after lyophilization was carried out. The changes in the dynamics of the clotting time, the activity of serum aminotransferases, the duration of prefebrile period and survival time were analysed in different cases. No lethality was observed in animals infected with small doses of aerosol preparations.