Anti-arrhythmia effects of enkephalinase inhibitors
Lishmanov, I.B.; Maslov, L.N.; Uskina, E.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 64(5): 28-30
2001
ISSN/ISBN: 0869-2092 PMID: 11764494 Document Number: 530524
The intravenous pretreatment with enkephalinase inhibitors KB 101 and acetorphan increased the heart resistance to the arrhythmogenic action of adrenaline (epinephrine), is related to activation of the delta-opioid receptors by endogenous enkephalins. At the same time, the mu-receptors and their endogenous agonists play an insignificant role in development of the antiarrhythmic effect of acetorphan. The enkephalinase inhibitors are a promising group of compounds for the development of new antiarrhythmic drugs, because these agents, in contrast to opiates, do not lead to narcotic addiction.