Application of FAM networks in recommendation of mobile phase for RP-HPLC
Gao, S.G.; Li, R.; Xiang, B.R.
Yao Xue Xue Bao 36(9): 676-678
2001
ISSN/ISBN: 0513-4870 PMID: 12580106 Document Number: 530397
To establish expert system to recommend solvent strength in RP-HPLC by using FAM (fuzzy associate memorizer) networks. Symbolic rules reflecting the quantitative relationship among molecular structure, capacity factors and solvent strength in RP-HPLC were extracted from trained radial basis function networks. Then FAM networks consisting of these rules were built to recommend mobile phase strength for RP-HPLC. The validation results of the system by monocomponent and mutilcomponent drug samples were satisfied. The mobile phase recommendation system for RP-HPLC analysis of drugs showed reliable performance.