Infrequent deletion in 67 codon in HIV reverse transcriptase in antiretroviral treatment failure
Giri, J.; Jáuregui Rueda, H.; Monticelli, A.; Pirola, D.A.; Planes, N.
Medicina 61(2): 193-195
2001
ISSN/ISBN: 0025-7680 PMID: 11374145 Document Number: 528852
We present a clinical case of antiretroviral treatment failure with appearance of mutations demonstrated by genotyping. We also show the evolution of the pattern of mutations that confers resistance to protease and reverse transcriptase inhibitors along with changes in the scheme of drugs indicated to the patient. A deletion was found in codon 67 of the TR gen, along with a novel resistance model to AZT pointing out the benefits of the detection of antiviral resistance by sequencing (genotyping).
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