Experience in studying antigenic activity of inactivated hepatitis A vaccine
Shumilov, V.I.; Shevtsov, V.A.; Lobastov, S.P.; Materiov, A.M.; Vardanian, N.V.; Nikolaeva, E.I.
Voenno-Meditsinskii Zhurnal 322(12): 52
2001
ISSN/ISBN: 0026-9050 PMID: 11881479 Document Number: 528488
The results obtained during the study of antigeneity of inactivated vaccines against hepatitis A ("Avaxim", France; "Hep-A-in-VAC", Russia; "Havrix", Belgium) used in troop units and RF MD institutions are presented in the article. The aim of the investigation is choice of the drug that provides the production of antibody protective levels in maximally short periods. It is very important for the army collectives sent to the zones of armed conflicts and HAV epidemic centres. It is shown that the most acceptable vaccine is "Avaxim" that provides the highest percentage of seroconversion (93.75%) with antibody level not less than 125 mIU/ml. It is recommended to consider this level as the protective one in conditions of army collectives.