Evaluation on the cytotoxicity of Gallium alloy by MTT-assay
Xu, G.; Zhang, C.; Ning, L.
Zhonghua Kou Qiang Yi Xue Za Zhi 36(3): 189-192
2001
ISSN/ISBN: 1002-0098 PMID: 11812339 Document Number: 527316
To test the cytotoxicity of Gallium alloy, a new mercury-free dental restorative material. L-929 mouse fibroblasts were used to detect the cell relative proliferation rate of Gallium alloy and high-copper amalgam by MTT-assay. The results indecated that the relative growth rate induced by Gallium alloy was high (93.0% +/- 4.9% 2ds, 102.0% +/- 3.5% 4ds, 107.2% +/- 4.2% 7ds), and the cytotoxicity of Gallium alloy was 0 grade according to the Test Standard of Shanghai Medical Biomaterial, meaning Gallium alloy had no significant cytotoxicity and the relative growth rate of Gallium alloy was higher than that of high-copper amalgam. The high-copper amalgam showed medium cytotoxicity. Gallium alloy has no significant cytotoxicity.