New observations support the significance of angiogenesis in myeloma
Lundberg, L.G.; Lerner, R.; Palmblad, J.
Lakartidningen 98(45): 4985-4990
2001
ISSN/ISBN: 0023-7205 PMID: 11816901 Document Number: 526657
Angiogenesis appears to be a prominent feature of many hematological disorders, in particular multiple myeloma. The remissions achieved when treating patients with advanced myeloma with the angiostatic drug thalidomide suggested that the disease might be angiogenesis-dependent. However, the mechanisms for the beneficial effect of thalidomide are, at this time, rather unclear, and may involve other effects beside angiostasis. Nonetheless, these and other observations have spurred an interest in angiogenesis that might lead to new concepts and treatment modalities. Here, an update concerning angiogenesis and multiple myeloma is presented.