Structural basis of the intracortical synchronization of epileptic potentials in the sensomotor region of the rat neocortex
Pasikova, N.V.; Marchenko, V.G.; Kositsin, N.S.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 86(5): 532-540
2000
ISSN/ISBN: 0869-8139 PMID: 10885015 Document Number: 525826
In control rats, penicillin-induced epileptiform discharges were completely synchronous in the neocortex sites at a distance of up to 4 mm from each other. Number of the cells decreased by 45.5% during 90 days in isolated cortical slabs and the synchronisation disappeared. The data obtained show that the loss of large pyramidal neurones of the layer V entailed a loss of the spatial synchronisation. The main axonal collaterals of large pyramidal neurones of the layer V could be followed horizontally for a distance of up to 2 mm in the somatosensory cortex. The neuronal network formed by the large pyramidal neurones of the layer V seems to provide a spatial synchronisation in the neocortex.