Endocarditis caused by Corynebacterium diphtheriae tolerant to amoxicillin
Dupont, C.; Turner, L.; Rouveix, E.; Nicolas, M.H.; Dorra, M.
Presse Medicale 24(24): 1135
1995
ISSN/ISBN: 0755-4982 PMID: 7567828 Document Number: 5258
Sur le plan bactériologique, l'ampicilline comme l'amoxicilline-acide clavulanique n'etaient que bactériostatiques. En association avec la nétilmicine, le sérum est bactéricide au 1/16 en 4 heures. Ceci correspond a des mutations apparues vers 1965-70 (Europe - USA pour la pénicilline) et vers 1980 pour l'ampicilline. Des mutations pourraient expliquer la tolérance de certaines souches.
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