The relationship among proinsulin and true insulin to coronary artery disease
Zhu, Z.; Li, M.; Chen, D.; Zhang, K.; Wu, C.; Ji, B.
Zhonghua Nei Ke Za Zhi 39(12): 814-817
2000
ISSN/ISBN: 0578-1426 PMID: 11798542 Document Number: 524605
Whether proinsulin (PI) and true insulin (TI) are independently related to coronary artery disease (CAD). 54 patients with CAD diagnosed by coronary angiography and/or intravascular ultrasound, 37 patients without CAD by coronary angiography and/or intravascular ultrasound and 23 healthy volunteers. All subjects had oral glucose tolerance test after an overnight 14 h fast. PI and TI concentrations were detected at different phases by BA-ELISA in which PI cross -reactivity is less than 0.1%. Fasting and post-glucose loading PI and TI levels in both CAD and non-CAD groups significantly increased when compared with the control group (P < 0.05), after adjustment for age, body mass index and waist hip ratio, all statistically significant associations weakened or disappeared among three groups; but there was no significant difference of all the above variables between CAD group and non-CAD group (P > 0.05). PI and TI, whether fasting or post-glucose loading, may not be independently related to CAD.