Role of putative neurotransmitters in cannabis-induced analgesia in rats

Ghosh, P.; Bhattacharya, S.K.

Indian Journal of Medical Research 72: 449-453

1980


ISSN/ISBN: 0019-5340
PMID: 6109695
Document Number: 524
The role of brain monoamines and endorphins in the analgesic action of cannabis resin (CI) was investigated in rats, using pharmacological agents which influence brain monoamine and opiate receptor activity. .delta.-9-tetrahydrocannabinol content of CI was estimated to be 17%. The analgesic effect of CI was significantly inhibited by drugs which reduce brain serotonin activity but was unaffected by drugs reducing brain catecholamine activity. The analgesic effect of a subanalgesic dose of CI was potentiated by serotonin precursors but not by catecholamine precursors. Potentiation of the analgesic action of CI by nialamiamide or imipramine was inhibited after pretreatment with 5,6-dihydroxytryptamine. Pretreatment with naloxone, a specific opioid receptor antagonist, markedly attenuated CI analgesia. The analgesic action of CI is serotonin-mediated with possible involvement of endorphins.

Document emailed within 1 workday
Secure & encrypted payments

Role of putative neurotransmitters in cannabis-induced analgesia in rats