Putative peptide neurotransmitters in human neuropathology: a review of topography and clinical implications
Constantinidis, J.; Bouras, C.; Richard, J.
Clinical Neuropathology 2(2): 47-54
1983
ISSN/ISBN: 0722-5091 PMID: 6189657 Document Number: 215297
In Huntington's disease, there is a decrease of the neuropeptides, substance P, enkephalins, and cholecystokinin in the striatonigral system, whereas in Parkinson's disease an increase of substance P is found in the substantia nigra. Several neuropeptides should be involved in Alzheimer's disease: substance P, endorphins, vasopressin, ACTH, somatostatin, vasoactive intestinal peptide, cholecystokinin, neurotensin, delta sleep-inducing peptide. Alterations of substance P, vasoactive intestinal peptide, cholecystokinin, somatostatin, and endorphins may be related to the pathophysiology of schizophrenia. Delta sleep-inducing peptide may interfere in addiction pathology.