Regulatory mechanisms of erythropoiesis by leukocytes in inflammation
Klimenko, M.O.; Shevchenko, O.M.
Fiziolohichnyi Zhurnal 46(5): 41-46
2000
ISSN/ISBN: 2522-9028 PMID: 11269852 Document Number: 523494
On the model of carrageenan-induced acute aseptic peritonitis in rats with use of the inhibitors of some leukocytic products it is shown that lysosomal proteinases inhibit erythropoiesis activation in inflammation. Lipoxygenase metabolites stimulate erythropoiesis. Eicosanoids as a whole stimulate erytropoiesis still more. Reactive oxygen species promote the development of erythron hyperplasia. Dexamethasone administration increases the erythropoiesis intensification.