The morphological changes and cytochemical profile of the leukocytes in regulatory disorders of glucocorticoid secretion in the postresuscitation period
Lobov, V.V.; Tagil'tseva, M.P.; Pospelov, V.S.; Kazakova, A.V.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1991(4): 14-17
1991
ISSN/ISBN: 0031-2991 PMID: 1798640 Document Number: 375531
It was shown in experiments on dogs who experienced death from blood loss that regulation of glucocorticoid secretion changes in phases. The changes are characterized by its disturbance in the first 3 days and a tendency to restoration 7 days after return to life. Disorders of function of the hypothalamo-hypophyseal-adrenal system were attended by a change of the intensity of metabolic processes in the leukocytes which depended on the duration of the circulatory arrest. On the 7th day of the postresuscitation period "dexamethasone depression" caused morphological and cytochemical changes of the leukocytes, which resembled those in intact animals.