Phospholipase A2-activating protein--an important regulatory molecule in modulating cyclooxygenase-2 and tumor necrosis factor production during inflammation
Ribardo, D.A.; Peterson, J.W.; Chopra, A.K.
Indian Journal of Experimental Biology 40(2): 129-138
2002
ISSN/ISBN: 0019-5189 PMID: 12622174 Document Number: 9601
Inflammation is a complex multifactorial process and a hallmark of many inflammatory diseases. Most of the tissue destruction that occurs in these diseases is the result of an aberrant or often uncontrolled immune response. Factors that play an important role in such diseases include pro-inflammatory cytokines, complement, and eicosanoids. This review focuses on eicosanoids and their regulation via phospholipase A2-activating protein, which could be targeted as a new therapeutic tool to control inflammatory diseases.
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