Role of neutrophils in regulation of immune responsiveness and reparative reactions of damaged tissue
Dolgushin, I.I.; Zurochka, A.V.; Chukichev, A.V.; Kolesnikov, O.L.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2: 14-19
2000
ISSN/ISBN: 0869-6047 PMID: 10723258 Document Number: 522674
After both thermal and mechanical injuries, mice are shown to have depressed functions of phagocytes (primarily neutrophils), suppressed ability of an immune response to antigens and decreased skin inflammatory and reparative activities. It is suggested that a neutrophilic secretory defect and a decrease in the production of stimulating factors might be a cause of the above effects. After thermal and mechanical injuries, injection of neutrophilokin extracted from latex-activated neutrophilic supernatant into the mice promoted recovered phagocytic functional activity, higher humoral and cellular immune response and increased the rate of standard burn wound healing. Neutrophilokin also accelerated clavus formation in mice with mechanical injury. Thus, it can be concluded that neutrophils and their low-molecular secretory products play an important role in regulating immune and inflammatory reparative homeostasis in thermal and mechanical injuries.