Cardiotoxicity of anthracycline
Wojtukiewicz, M.Z.; Omyła, J.; Kozłowski, L.; Szynaka, B.
Postepy Higieny i Medycyny Doswiadczalnej 54(4): 467-485
2000
ISSN/ISBN: 0032-5449 PMID: 11016267 Document Number: 521480
The anthracyclines are among the most active and useful anticancer agents, but they are also the most common chemotherapeutics associated with the development of congestive heart failure. Twenty seven to sixty percent of patients with anthracycline-induced cardiomyopathy die of congestive cardiac failure. The paper presents the pathomechanisms of anthracycline-induced cardiotoxicity and perspectives on prevention of congestive heart failure resulting from anthracycline chemo-therapy.