Dose the serum brain natriuretic peptide (BNP) level after open heart surgery reflect myocardial protection?
Shirasawa, B.; Hamano, K.; Kawamura, T.; Gohra, H.; Katoh, T.; Fujimura, Y.; Zempo, N.; Esato, K.
Kyobu Geka. Japanese Journal of Thoracic Surgery 53(2): 123-126
2000
ISSN/ISBN: 0021-5252 PMID: 10667022 Document Number: 520192
This clinical study was conducted to determine whether the serum BNP level after open heart surgery reflects myocardial protection. The levels of BNP and CPK-MB were measured before and after 12 hours of cardiopulmonary bypass, then 1, 3, and 6 days after open heart surgery, and the relationship between the maximum levels of BNP and the CPK-MB after open heart surgery was examined. The patients were divided into two groups according to whether or not the maximum CPK MB was more than 100 IU/l after open heart surgery. A significant relationship between the maximum BNP and the maximum CPK-MB after open heart surgery was observed (p = 0.013). Moreover, the BNP was significantly increased in the group of patients with a maximum CPK-MB > or = 100 IU/l, compared to that in those with a maximum CPK-MB < 100 IU/l, 12 hours 1 day, and 6 days after open heart surgery (p < 0.01). These findings indicate that the serum level of BNP after open heart surgery can reflect myocardial protection.