Comparative Evaluation of B-Type Natriuretic Peptide and Mid-Regional Pro-A-Type Natriuretic Peptide Changes from Admission to Discharge in Prognosis of Acute Decompensated Heart Failure Patients
Stenner, E.; Buiatti, A.; Barbati, G.; Merlo, M.; Sinagra, G.; Biasioli, B.
Clinical Laboratory 58(5-6): 585-589
2012
ISSN/ISBN: 1433-6510 PMID: 22783593 Document Number: 11602
Background: Mid-regional pro-A-type natriuretic peptide (MRproANP) seems to be non-inferior compared to B-type natriuretic peptide (BNP) for heart failure diagnosis and prognosis; however, no previous studies have investigated the MRproANP in-hospital changes in prognostic role. This study aimed to compare the prognostic accuracy of BNP and MRproANP in-hospital changes in acute decompensated heart failure (ADHF) patients. Methods: 37 patients with either admission/predischarge BNP and MRproANP data, were investigated. The combined endpoint was cardiovascular death/heart transplantation/readmission for HF. Results: BNP and MRproANP had a median decrease of 55% [72;45] and 21% [40; 11] respectively in event-free patients; BNP decrease of 34% [48;29] but MRproANP increase of 4% [-7; 25] in patients with cardiovascular events. Prognostic accuracy of deltaBNP and deltaMRproANP was similar. Conclusions: MRproANP basically trends up in patients with worse outcome and decreases in event-free patients, likely leading to a simpler interpretation although the prognostic accuracy is similar for both peptides.
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