Direct effects of fluoride on activities of bone morphogenetic protein
Xu, S.; Zheng, G.; Li, M.; Shu, B.
Zhonghua Yu Fang Yi Xue Za Zhi 34(4): 215-217
2000
ISSN/ISBN: 0253-9624 PMID: 11860933 Document Number: 519594
To demonstrate the direct effects of fluoride on activities of bone morphogenetic protein (BMP). A complex sample containing BMP and sodium fluoride was implanted under the abdominal skin of young male Wistar rats. The histological characteristics, and activities of alkaline phosphatase and acid phosphatase of the implanted were examined to study the effects of fluoride on biological activities of BMP. More fibroblasts cell were transformed to osteoblasts cell in animals treated by BMP with fluoride than those treated by BMP only. During bone formation induced by BMP, fluoride increased the activities of osteoblasts and accelerate mineralization, while inhibited the activities of osteoclast. Fluoride can affect biological activities of BMP directly.