Midodrine (Gutron) treatment of permanent arterial hypotension in a chronic hemodialysis patient
Montagnac, R.; Clavel, P.; Delhotal-Landes, B.; Flouvat, B.; Poulain, S.; Schillinger, F.
Nephrologie 21(4): 179-183
2000
ISSN/ISBN: 0250-4960 PMID: 10976433 Document Number: 519169
Chronic hypotension, although unfrequent in uremic patients on hemodialysis, accentuates the deterioration of patients physical state and thus, their general well-being. These patients often experience acute intradialytic symptoms and respond very poorly to conventional therapies. Well tolerated, midodrine is a suitable and effective choice as it raises blood pressure significantly through its effect on peripheral alpha-adrenergic receptors. The authors report observing the use of midodrine by a dialysis patient during the longest time period published to date, documented by a pharmacokinetic study, and that confirms the excellent results and proves long term tolerance for that drug.