Long-acting isosorbide dinitrate and molsidomin in the treatment of effort angina in patients with arterial hypotension
Idrisova, E.M.; Kladieva, E.A.; Borovkova, N.V.; Vorob'eva, E.V.; Chernov, V.I.; Karpov, R.S.
Terapevticheskii Arkhiv 74(6): 63-66
2002
ISSN/ISBN: 0040-3660 PMID: 12136489 Document Number: 548277
Aim: To compare effectiveness and tolerance of isosorbide dinitrate (ID) and molsidomin in retard forms in patients with effort angina (EA) in combination with arterial hypotension (AH). Material and methods: A randomised blind cross-over trial with lead-in placebo period trial compared efficiency of retard ID and molsidomin in 65 EA patients with AH (group 1) and 40 normotensive patients with coronary heart disease (group 2). Results: Bicycle exercise has shown that retard ID and molsidomin retard were highly effective in group 1 (97% vs 92%0 and group 2 (100 and 95%, respectively). Molsidomin retard treatment improved myocardial perfusion and was effective for a year in both groups. Conclusion: Retard ID was highly effective in anginal patients with AH but its tolerance is also high. Molsidomin retard is proposed as alternative treatment in anginal patients with AH.