Clinical significance of P-glycoprotein and CD34 expression of acute leukemia
Lin, X.M.; Xie, Z.X.; Zhu, P.A.
Hunan Yi Ke da Xue Xue Bao 25(2): 171-172
2000
ISSN/ISBN: 1000-5625 PMID: 12212213 Document Number: 518801
The expression of P-glycoprotein(P-170) and CD34 was detected in the bone marrow mononuclear cells of 30 patients with acute leukemia by immunocytochemical technique using JSB-1 and Tük 3 monoclonal antibody. The results were that expression of P-170 and CD34 had no significant difference between acute nonlymphoblastic leukemia and acute lymphoblastic leukemia(P > 0.05). The clinical therapeutic effect was poor in P-170 or CD34 positive patients and had significant difference compared with those negative patients(P < 0.05). Judgments of therapeutic effect for acute leukemia can be improved by detecting the expression of P-170 and CD34 simultaneously.