Depression of serum pyridoxal levels in theophylline-related seizures
Seto, T.; Inada, H.; Kobayashi, N.; Tada, H.; Furukawa, K.; Hayashi, K.; Hattori, H.; Matsuoka, O.; Isshiki, G.
No to Hattatsu 32(4): 295-300
2000
ISSN/ISBN: 0029-0831 PMID: 10916367 Document Number: 515207
In order to study whether a theophylline-related seizure is caused by a decrease in serum vitamin B6, serum pyridoxal (PAL) levels were measured in children with bronchial asthma treated with theophylline. The serum PAL levels of asthmatic children (n = 31) treated with theophylline were significantly lower than those of control subjects (n = 21). Moreover, we evaluated PAL levels in four subjects within twenty-four hours after a seizure with or without fever. The level was low in three of the four. These results suggest that the decrease in PAL levels caused by theophylline may lower the seizure threshold.