Monitoring serum theophylline levels in children. use of saliva for prediction
Dolezalová, K.; Martínková, J.; Kopecká, J.; Kuralová, Z.; Etlerová, E.
Ceskoslovenska Pediatrie 44(10): 592-596
1989
ISSN/ISBN: 0069-2328 PMID: 2620353 Document Number: 327208
In 28 children suffering from asthma--20 boys and 8 girls aged 3-19 years, weighing 18-79 kg--theophylline concentrations in serum and saliva were assessed. For detection the spectrophotometric method of Schack and Waxler and the fluoroimmunoassay TDA AMES were used. Under conditions of non stimulated salivary secretion the pH values of the secretion varied as a rule between 6.0 and 7.5 which did not influence significantly the amount of theophylline passing from blood into saliva. The authors found a very close correlation between the theophylline concentrations after administration of Syntophylline in saliva and serum (r = 0.9169, p less than 0.001) and Spophylline (r = 0.9369, p less than 0.001). Comparison of serum theophylline concentrations calculated from the salivary values on the one hand and the same serum theophylline concentrations actually assessed revealed that their difference varied up to 1 microgram.ml-1.