Cytomorphological study of cultured mammalian cells treated with benzaldehyde, catechol and their derivatives with special reference to inhibition of DNA synthesis

Nishimura, M.; Umeda, M.; Kusanagi, A.; Urakabe, R.; Yukimatsu, K.; Otawara, S.

Gan 72(2): 272-279

1981


ISSN/ISBN: 0016-450X
PMID: 7197242
Document Number: 5151
Cytotoxicity and cytomorphological changes induced in cultured mammalian cells by the application of benzaldehyde, pyrocatechol and their derivatives were examined. Among the compounds tested, 3,4-dihydroxybenzaldehyde (protocatechualdehyde) and 1,2-dihydroxybenzene (pyrocatechol) produced cytomorphological changes characteristic of specific inhibitors of DNA synthesis in V79 cells and EJ-1 cells. However, they did not induce such changes in HeLa cells. 2,3-Dihydroxybenzaldehyde and catecholamines did not produce such characteristic changes in V79 cells. The cytological effects of protocatechualdehyde and pyrocatechol were confirmed by a study on the incorporation of 3H-precursors of DNA, RNA and protein into 3 cell lines.

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Cytomorphological study of cultured mammalian cells treated with benzaldehyde, catechol and their derivatives with special reference to inhibition of DNA synthesis