Cellular aspects of folate and antifolate membrane transport
Brzezińska, A.; Wińska, P.; Balińska, M.
Acta Biochimica Polonica 47(3): 735-749
2000
ISSN/ISBN: 0001-527X PMID: 11310973 Document Number: 514751
Folates--one carbon carriers--take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.
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