Expression of ET of early ischemic myocardium in rats
Ma, M.; Xu, X.; Luo, B.; Wu, X.; Zhu, J.
Fa Yi Xue Za Zhi 16(3): 141-142; 191
2000
ISSN/ISBN: 1004-5619 PMID: 12536415 Document Number: 514117
To study the expression of ET of early ischemic myocardium, we designed a model of early myocardial ischemia (EMI) in rats. The study was conducted with SABC method and HE staining. Cardiac myocytes of ischemia showed a little ET-positive at 60-min. Cardiac myocytes, endothelium and smooth muscle of vessel showed ET-positive staining in the area of EMI after 120-min. Staining was negative for Ischemia myocardium at 30-min and for the control group. No change was seen with HE staining in all groups. The data indicates that ET-SABC method may reveal the injury of myocardial ischemia 60-min and longer and may provide a new marker to diagnose EMI in forensic pathology.