Megestrol-induced clinical adrenal insufficiency
Goodman, A.; Cagliero, E.
European Journal of Gynaecological Oncology 21(2): 117-118
2000
ISSN/ISBN: 0392-2936 PMID: 10843465 Document Number: 513578
Objective: To describe a case of megestrol-induced adrenal insufficiency. Methods: A patient who received megestrol and then developed pituitary-adrenal axis abnormalities is described. The literature is reviewed. Results: The patient developed megestrol-induced Cushingoid features. She developed adrenal insufficiency when megestrol was stopped. Conclusion: Megestrol can induce alterations of the pituitary-adrenal axis in some patients. It is important to consider a diagnosis of adrenal insufficiency in patients with symptoms of fatigue, hypotension, and asthenia who have been treated with megestrol.