Clinical efficacy and safety of megestrol acetate vaginal ring
Qian, J.-f.; Zhu, X.-y.; Shen, Y.-w.; Huang, Z.-r.
Zhonghua Yi Xue Za Zhi 93(31): 2490-2492
2013
ISSN/ISBN: 0376-2491 PMID: 24300272 Document Number: 622912
To explore the efficacy and safety of megestrol acetate silicone vaginal ring. A total of 165 healthy child-bearing age women were recruited to examine the efficacy, safety and satisfaction rate of megestrol acetate silicone vaginal ring. The cumulative pregnancy rate of megestrol acetate silicone vaginal ring was 3.93%. And its discontinuation rate was 2.54%, the incidence of adverse events 11.52% and the incidence of adverse effects 1.81% while the symptoms were all slight. The bleeding pattern was similar to that of normal menstruation. Compared with baseline, the elevated level of triglycerides and the reduced level of low-density lipoprotein (LDL) were significantly different while no significant difference existed in high-density lipoprotein (HDL), cholesterol and hemoglobin, etc. The satisfaction rate of megestrol acetate silicone vaginal ring was 94.6% and increased with time. Megestrol acetate silicone vaginal ring is an effective and safe option of contraceptives.