The activation of soluble guanylate cyclase by new NO donors as the basis of a directed search for new efficacious vasodilators and antiaggregants
Severina, I.S.; Bussygina, O.G.; Piatakova, N.V.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 4: 25-30
2000
ISSN/ISBN: 0869-6047 PMID: 10832410 Document Number: 513481
The paper deals with the molecular mechanisms of antihypertensive and antiaggregatory actions of nitric oxide (NO). These effects of NO are shown to be directly associated with the activation of soluble guanylate cyclase and with the accumulation of 3',5'-guanosine monophosphate. The paper discusses the mechanism of activation of guanylate cyclase with new donors: the role and value of a nitrosyl-hemic complex formed in the interaction of guanylate cyclase with NO. New approaches to studying the mechanism of antihypertensive and antiaggregatory actions of the NO donors in question provided fundamental and priority data that lead to the development of the molecular bases of goal-oriented search and the synthesis of new effective vasodilators and antiaggregants. Examining the molecular mechanisms of targeted activation of soluble guanylate cyclase with new NO donors has revealed new enzyme activators that generate NO in the body and participate in the regulation of homeostasis and vascular tone.