Effect of a novel aminosteroid on animal model of murine myelomonocytic leukemia
Na, X.D.; He, Q.; Jiang, D.Z.
Hunan Yi Ke da Xue Xue Bao 25(1): 12-14
2000
ISSN/ISBN: 1000-5625 PMID: 12212233 Document Number: 512624
To evaluate the effect of a novel aminosteroid on murine myelomonocytic leukemia, BALB/c mice were treated by the novel aminosteroid for 7 days after receiving 1 x 10(6) WEHI-3B(myelomonocytic leukemia) cells intraperitoneally. The counts and classification of white blood cells obtained from tail blood were determined on the day before transplanting WEHI-3B cells and 7, 14, 21, 28 days after transplantation. Undifferentiated cell percentage of bone marrow and spleen weight were checked 30 days after transplantation. The results demonstrated that the above indexes of mice treated with the novel aminosteroid were decreased compared with those treated with normal saline(NS). Decrease of the indexes showed a dose-dependent relationship ranging from 5-20 mg.kg-1.d-1. It is suggested that leukemia mice could be effectively treated by the novel aminosteroid and the efficacy maybe paralleled with the dosage of the novel aminosteroid.