Acute myelocytic leukemia and chronic myelomonocytic leukemia simultaneously with resectable breast cancer: a report of two cases
Cavanna, L.; Vallisa, D.; Di Stasi, M.; Fornari, F.; Buscarini, E.; Schena, C.; Civardi, G.; Sbolli, G.; Berte, R.; Buscarini, L.
Tumori 78(5): 356-358
1992
ISSN/ISBN: 0300-8916 PMID: 1494812 Document Number: 389274
This report describes 2 patients who developed acute myelocytic leukemia (AML) type M2 and chronic myelomonocytic leukemia (CMML) of the FAB classification, respectively 2 months and 2 weeks after diagnosis of operable breast cancer. The patient with AML showed pancytopenia 2 months before the diagnosis of AML, had a normal karyotype, and showed a good response to chemotherapy. The patient with CMML had a normal karyotype, and she was treated with hydroxyurea and supportive therapy. The 2 patients had no previous exposure to irradiation or cytotoxic therapy. These cases show that breast cancer and either leukemia or myelodysplastic syndrome may be associated even without previous irradiation or combination chemotherapy.