Hemopoiesis in chronic myelomonocytic leukemia
Lugovskaia, S.A.; Morozova, V.T.; Lukina, E.A.; Kozlovskaia, A.S.; Gorodnicheva, V.F.; Sysoeva, E.P.
Klinicheskaia Laboratornaia Diagnostika 10: 8-11
1998
ISSN/ISBN: 0869-2084 PMID: 9864996 Document Number: 488188
Hemopoiesis and functional activity of monocytes were assessed in 30 patients with chronic myelomonocytic leukemia (CMML). Changes in haemogram in CMML are characterized by anemia, thrombocytopenia, normal or increased count of leukocytes with absolute monocytosis and increased count of young granulocytes. Bone marrow hemopoiesis is characterized by enhanced proliferation of cellular elements of granulocytopoiesis and monocytes, suppressed erythropoiesis and megakaryocytopoiesis. Dysplastic changes are most expressed in the erythrocytic stem cells. Studies of lysosomal enzymes showed their increased activity in monocytes of CMML patients.