Physiopathology of nephropathy studied with contrast media
Morales Buenrostro, L.E.; Tellez Zenteno, J.F.; Torre Delgadillo, A.
Revista de Investigacion Clinica; Organo del Hospital de Enfermedades de la Nutricion 52(3): 306-313
2000
ISSN/ISBN: 0034-8376 PMID: 10953614 Document Number: 512168
For the technological advances in diagnostic and therapeutic procedures, the use of intravenous contrast media in the hospital is more and more frequent. It can produce acute renal failure secondary to its nephrotoxicity known as contrast media nephropathy. This review describes the pathophysiologic mechanisms of contrast media injury, including cytotoxicity caused by hyperosmoloarity of contrast media, the hemodynamic factors and the role of the renin-angiotensin system, prostaglandins, oxygen free radicals, endothelin-1, adenosine, nitric oxide and others. The understanding of this information is of vital importance for the development of prophylactic strategies for contrast media nephropathy.