Effect of presynaptic dopaminergic agonism on the immobility of mice in the forced swimming test
Vamvakidès, A.
Annales Pharmaceutiques Francaises 57(5): 374-379
1999
ISSN/ISBN: 0003-4509 PMID: 10520507 Document Number: 511658
Administration of 0.05 mg/kg (i.p.) of apomorphine (APO) or of the two dopamine (DA) lipoamides, DA steatamide (S-DA) or DA palmitamide (P-DA), at doses of 10 or 30 mg/kg (i.p.), induced an anti-immobility effect, in the forced swimming test in mice, of the same order as those of imipramime (30 mg/kg, i.p.). At the aforementioned doses APO, S-DA or P-DA could be acting on the dopaminergic autoreceptors and cause a decrease of the turnover and/or the release of the brain DA in the striatum. In contrast, DA linoleamide (L-DA), which has no action on the brain DA, did not exhibit anti-immobility effect. It is suggested that the decrease of turnover and/or release of the brain DA, induced by APO, S-DA or P-DA, could constitute a clue of the extent of the extrasynaptic action developed by these drugs whose antiglutamatergic incidence could cause the anti-immobility effect, observed with these derivatives, as well as their possible antidepressive action.