Chronic treatment with tween-80 (5%) or n-stearoyl glycine on the antimobility effects of imipramine in the forced swimming test in mice
Vamvakidès, A.
Bollettino Chimico Farmaceutico 135(10): 603-604
1996
ISSN/ISBN: 0006-6648 PMID: 9081294 Document Number: 457134
Chronic (7 days) administration of N-stearoyl glycine (SG) or Tween-80 (5%) suppress the antiimmobility effect of Imipramine, in the forced swimming test on mice, whereas the antiimmobility effect of SG is suppressed only after chronic treatment with SG. These results suggest that chronic SG treatment could desensitize the glycinergic site of the NMDA receptors and that chronic Tween-80 (5%) administration could inactivate the glutamatergic site of the NMDA receptors or disturb some modulation, other than glycinergic, of the NMDA ionic channel. The latter could be important in an environmental or experimental viewpoint.