Role of proteinase inhibitors in the process that provide coupling between body's functional systems
Gurin, V.N.; Sandakov, D.B.; Gurin, A.V.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 6: 25-29
1999
ISSN/ISBN: 0869-6047 PMID: 10432860 Document Number: 511350
The authors make an attempt to substantiate the idea that proteinase inhibitors can produce a noticeable effect on the integration of functions. It is suggested that proteinase inhibitors play a special role in providing coupling between the body's functional systems in the conditions that may disturb the structural and functional integrity of the organism. They paper provides experimental evidence for the effect of the serine proteinase inhibitor alpha 1-antitrypsin on the thermal regulatory system and couples functional systems that provide behavioral responses. Possible mechanisms of systemic action of proteinase inhibitors and their involvement in the integrative activity of the nervous system are discussed.