Diagnostic value of determining endogenous proteinase inhibitors in cancer patients
Shcherbak, I.G.; Potashov, L.V.; Levin, A.O.; Kulikova, A.I.; Sitkevich, R.V.
Voprosy Onkologii 33(3): 22-26
1987
ISSN/ISBN: 0507-3758 PMID: 2436380 Document Number: 288007
Patients with stage III and IV cancers of different sites revealed a 47-76% increase in serum total antitrypsinic activity. A mean 40% increase was observed in cases of inflammatory pathology. Both study groups demonstrated raised alpha 1-antitrypsin levels, while that of alpha 2-macroglobulin did not show any significant changes. The level of alpha 1-antitrypsin accounted for 89 and 83% of total antitrypsinic activity in cases of inflammation and controls, respectively, while in cancer patients this index was significantly lower (70%). The diagnostic value of total antitrypsinic activity appeared to be higher than that of alpha 1-antitrypsin level determination. It is inferred that, apart from alpha 1-antitrypsin, malignant growth is associated with raised levels of more specific endogenous proteinase inhibitors, except alpha 2-macroglobulin.