Proteinase inhibitors in implantation and intrauterine device induced bleeding

Srivastava, K.

Malaysian Journal of Reproductive Health a Publication of the Reproductive Research Centre of the National Population and Family Development Board Malaysia 8(2): 55-57

1990


ISSN/ISBN: 0127-3213
PMID: 12343149
Document Number: 366775
Preliminary studies on the use of proteinase inhibitors to block implantation in rats are reported. There are 7 known plasma proteinase inhibitors which occur in plasma and tissue exudates. They function mainly to balance blood coagulation proteinases, but also are known to inhibit blastocyst proteinase and thereby block implantation. Proteinases occur in human endometrium, uterine fluid and placenta, and have been reported in organ cultures, but their significance in the regulation of implantation is unknown. Studies in laboratory animals document less bleeding and inflammation when animals bearing IUDS were treated with proteinase inhibitors such as aprotinin (Trasylol) and epsilon aminocaproic acid, but the contraceptive effect of the IUDs was reversed with these treatments. While 300 IU of Trasylol injected intrauterine prevented implantation in 7 rats, only 1000 IUD reversed the effect of IUDs in 7 rats.

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