Inhibition of lipopolysaccharide (LPS) -induced endothelial cytotoxicity by diosmin
Melzig, M.F.; Loose, R.
Die Pharmazie 54(4): 298-299
1999
ISSN/ISBN: 0031-7144 PMID: 10234742 Document Number: 510326
The cytotoxic effect of lipopolysaccharide (LPS) on cultivated bovine aortic endothelial cells was determined. This LPS-induced cytotoxicity was attenuated by diosmin. That means, the IC50-value of LPS in the combination with 8 mumol/l diosmin was shifted from 31 to 70 ng/ml in a concentration dependent manner. As a hypothesis it was suggested, that the inhibition of LPS-induced cytotoxicity in bovine aortic endothelial cell cultures by diosmin could be probably mediated via inhibition of tyrosine kinases.