Humoral immunity and protection of mice challenged with homotypic or heterotypic parvovirus
Hansen, G.M.; Paturzo, F.X.; Smith, A.L.
Laboratory Animal Science 49(4): 380-384
1999
ISSN/ISBN: 0023-6764 PMID: 10480642 Document Number: 508925
Infant mice without maternal antibody or antibody to minute virus of mice (MVM) or mouse parvovirus (MPV) and young adult mice given normal mouse serum or antibody to MVM or MPV were challenged with homotypic or heterotypic virus. In situ hybridization with target tissues was the indicator of infection. Humoral immunity failed to confer protection against acute heterotypic parvovirus infection. In passive transfer studies, MPV DNA was observed occasionally in lymph nodes, intestine or the spleen of MPV-challenged mice given homotypic antibody and kept for 6 or 28 days. Variable proportions of mice given MPV antibody and homotypic challenge had viral DNA in lymphoid tissues 56 days after virus inoculation. It is concluded that a mouse or colony that has sustained infection with MVM or MPV is probably fully susceptible to infection with the heterotypic virus.