Immunomodulatory effect of shikonin derivatives isolated from Lithospermum canescens on cellular and humoral immunity in Balb/c mice
Pietrosiuk, A.; Skopińska-Rózewska, E.; Furmanowa, M.; Wiedenfeld, H.; Sommer, E.; Sokolnicka, I.; Rogala, E.; Radomska-Leśniewska, D.; Bany, J.; Malinowski, M.
Die Pharmazie 59(8): 640-642
2004
ISSN/ISBN: 0031-7144 PMID: 15378856 Document Number: 584041
The immunomodulatory activity of acetylshikonin (ACS) and isobutyrylshikonin (IBS) was studied in female and male inbred Balb/c mice, and in F1 hybrids (Balb/c x C3H). ACS and IBS were isolated from Lithospermum canescens (Boraginaceae) roots. Splenocytes from mice fed 40 micro g of ACS had higher proliferative potential in cultures with PHA than corresponding controls and also higher migratory in vitro activity than splenocytes obtained from control animals. ACS at a 40 micro g daily dose stimulated G-v-H reaction but inhibited it at a 200 micro g dose. IBS at a 40 micro g dose significantly increased humoral response.