Role of skeletal muscle in plasma ion and acid-base regulation after NaHCO3 and KHCO3 loading in humans
Lindinger, M.I.; Franklin, T.W.; Lands, L.C.; Pedersen, P.K.; Welsh, D.G.; Heigenhauser, G.J.
American Journal of Physiology 276(1): R32-R43
1999
ISSN/ISBN: 0002-9513 PMID: 9887175 Document Number: 508641
This paper examines the time course of changes in plasma electrolyte and acid-base composition in response to NaHCO3 and KHCO3 ingestion. It was hypothesized that skeletal muscle is involved in the correction of the ensuing plasma disturbance by exchanging ions, gasses, and fluids between cells and extracellular fluids. Five male subjects, with catheters in a brachial artery and antecubital vein, ingested 3.57 mmol/kg body mass NaHCO3 or KHCO3. While seated, blood samples were taken 30 min before ingestion of the solution, at 10-min intervals during the 60-min ingestion period, and periodically for 210 min after ingestion was complete. Blood was analyzed for gases, hematocrit, plasma ions, and total protein. With NaHCO3, arterial plasma Na+ concentration ( after ingestion of NaHCO3. In contrast, the net influx of K+ to tissues played an important role in removing K+ from the extracellular compartment after ingestion of KHCO3. Reprinted by permission of the publisher.